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Bisindolylmaleimide I (GF109203X) is a potent PKC inhibitor with IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ in cell-free assays, respectively, showing more than 3000-fold selectivity for PKC as compared to EGFR, PDGFR and insulin receptor.
Store at -20℃
|IC50||20 nM, 17 nM, 16 nM, and 20 nM for PKCα, PKCβI, PKCβII, and PKCγ|
|Targets||PKCα, PKCβ1, PKCβ2, PKCγ|
|Solubility||82 mg/mL (198.79 mM) in DMSO|
|Other Name||BIM I
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