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Microtubules are involved in a wide variety of cellular activities ranging from mitosis and transport events to cell movement and the maintenance of cell shape. Tubulin itself is a globular protein consisting of two poly-peptides (alpha and beta tubulin).
Alpha and beta tubulin dimers are assembled to 13 proto-filaments that form a microtubule of 22-nm diameter. Tyrosine ligase adds a C-terminal tyrosine to monomeric alpha tubulin. Assembled microtubules can again be detyrosinated by a cytoskeleton-associated carboxy-peptidase.
Dety -rosinated alpha tubulin is referred to as Glu-tubulin. Another post-translational modification of detyrosinated alpha tubulin is C-terminal polyglutamylation, which is characteristic of microtubules in neuronal cells and the mitotic spindle. This antibody makes an excellent loading control.
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|Other Names||Tubulin alpha-1B chain, Alpha-tubulin ubiquitous, Tubulin K-alpha-1, Tubulin alpha-ubiquitous chain, TUBA1B|
|Target/Specificity||Recombinant fusion protein containing a sequence corresponding to amino acids 1-451 of human alpha Tubulin|
|Format||Purified polyclonal antibody supplied in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.|
|Application||WB : 1:500 - 1:3000|
|ELISA : 1:5000 - 1:90,000|
|IHC : 1:500 - 1:2,000|
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