Benzamidine HCl is a reversible inhibitor of trypsin, trypsin-like enzymes, and serine proteases. A concentration of approximately 1 mM is used for general protease inhibition. To inhibit proteases from yeast, a range of 0.5 to 4.0 mM is used and it is for the most part interchangeable with pepstatin A.
In addition to being a strong competitive inhibitor of trypsin, benzamidine HCl has been also shown to be a strong competitive inhibitor of thrombin and plasmin. It was also found to be as effective as aprotinin in the prevention of glucagon degradation in human plasma.
Store at 2-8℃
| Synonym |
Amidinobenzene hydrochloride, Benzamidinium chloride, Benzenecarboximidamide hydrochloride |
| Solubility |
Water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow |
| mp |
86-88 °C (lit.) |
| Application |
Western blot analysis |
| Immunoprecipitation |
| Purification of yeast dynein |
| Protease inhibitor in the preparation of brush-border membrane vesicles |
| For the processing of human synovial fluid, blood and eye sleep |
| Prevent non-specific degradation of cartilages |
