The protein encoded by this gene is member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily included large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of determineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site.
This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5’ untranslated region of this gene has been described and three variants are described, all encoding an identical protein. Bone Morphogenetic Protein-4 Human Recomninant produced in E.Coli is monomeric, non-glycosylated, polypeptide chain containing 116 amino acids and having a molecular mass of 13kDa. The BMP-4 is purified by proprietary chromatographic techniques.