Search term Biomolecules has been found in the following products: 25

Biomolecules

BIO, 6-Bromoindirubin-3′-Oxime , BC2001

  • CAS No : 667463-62-9
  • Formula : C16H10BrN3O2
  • MW : 356.17
Collapse Store at -20℃
Cat No Size Price
BC2001-001 1mg $ 98.00 Add to cart
BC2001-010 10 mg $ 195.00 Add to cart
BC2001-050 50 mg $ 585.00 Add to cart
IC50 5 nM for GSK-3α/β in a cell-free assay, shows >16-fold selectivity over CDK5, also a pan-JAK inhibitor.
Target β-catenin phosphorylation on GSK-3-specific sites
Solubility The solubility of this compound in DMSO is >10 mM. General tips for obtaining a higher concentration: Please warm the tube at 37℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.
Alternative Names GSK-3α/GSK-3β inhibitor
6-bromoindirubin-3′-oxime (BIO) is a potent, reversible and ATP-competitive GSK-3α/β inhibitor and the first pharmacological agent shown to maintain self-renewal in human and mouse embryonic stem cells. Human embryonic stem cells (hESCs) are maintained in the undifferentiated state through treatment with a GSK-3 inhibitor, BIO, under a feeder-free condition.