Paclitaxel is an antitumor agent. Stabilizes microtubules and lowers the critical concentration for tubulin polyerization. Reversibly binds to polyerized tubulin.mInhibits protein isoprenylation and induces apoposis in PC-3 human prostatemcancer cells.
The checkpoint of mitotic spindle assembly, aberrant activation ofmcyclin-dependent kinases (CKDs) and the c-Jun N-terminal/stress activated protein
kinase (JNK/SAPK) are involved in Paclitaxel-induced apoptosis.