Search term Biochemical Reagent has been found in the following products: 35
Dasatinib, >99%, BC023
Data sheet- CAS No : 302962-49-8
- Formula : C22H26ClN7O2S
- MW : 488.01
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Store at -20℃
| Cat No | Size | Price | |
|---|---|---|---|
| BC023-500 | 500 mg | $ 115.00 | Add to cart  |
| BC023-101 | 1 g | $ 165.00 | Add to cart |
| IC50 | <1 nM, 0.8 nM and 79 nM in cell-free assays, respectively. Abl, Src and c-Kit |
|---|---|
| Targets | Abl, Src and c-Kit |
| Solubility | 98 mg/mL (200.81 mM) in DMSO |
Dasatinib reverses splenomegaly in LMP2A/MYC double transgenic mice. Dasatinib specifically prevents colony formation by LMP2A expressing bone marrow B cells and decreased spleen size in the TgE mice. Spleen mass is significantly decreased among Dasatinib treated Tg6/λ-MYC mice when compared to the control group. Dasatinib inhibits lymphadenopathy in LMP2A/MYC double transgenic mice. Dasatinib reverses splenomegaly in Rag1KO mice engrafted with tumor cells from LMP2A/MYC double transgenic mice. Dasatinib therapy inhibits Lyn phosphorylation in B lymphocyte tumors expressing LMP2A.
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