Search term Biochemical Reagent has been found in the following products: 29

Biochemical Reagent

Dasatinib, >99%, BC023

  • CAS No : 302962-49-8
  • Formula : C22H26ClN7O2S
  • MW : 488.01
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Cat No Size Price
BC023-500 500 mg $ 132.00 Add to cart
BC023-101 1 g $ 208.00 Add to cart
IC50 <1 nM, 0.8 nM and 79 nM in cell-free assays, respectively. Abl, Src and c-Kit
Targets Abl, Src and c-Kit
Solubility 98 mg/mL (200.81 mM) in DMSO
Dasatinib reverses splenomegaly in LMP2A/MYC double transgenic mice. Dasatinib specifically prevents colony formation by LMP2A expressing bone marrow B cells and decreased spleen size in the TgE mice. Spleen mass is significantly decreased among Dasatinib treated Tg6/λ-MYC mice when compared to the control group. Dasatinib inhibits lymphadenopathy in LMP2A/MYC double transgenic mice. Dasatinib reverses splenomegaly in Rag1KO mice engrafted with tumor cells from LMP2A/MYC double transgenic mice. Dasatinib therapy inhibits Lyn phosphorylation in B lymphocyte tumors expressing LMP2A.