Search term Biochemical Reagent has been found in the following products: 27

Biochemical Reagent

Bafilomycin A1, >95%, BC004

  • Purity ≥95%
  • M.W. C35H58O9
  • Formula Weight 622.8
  • CAS Number 88899-55-2
  • IC50 - 0.44 nM
  • Synonyms NSC 381866
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Cat No Size Price
BC004-001 1mg $ 235.00 Add to cart
BC004-005 5mg $ 980.00 Add to cart
Application Vacuolar H+-ATPase inhibitor
The bafilomycins are a family of macrolide antibiotic derived from Streptomyces griseus. These compounds all appear in the same fermentation and have quite similar biological activity. Bafilomycins are specific inhibitors of vacuolar-type H+- ATPase. The most used bafilomycin is bafilomycin A1.

This is a useful tool as it can prevent the re-acidification of synaptic vesicles once they have undergone exocytosis. Bafilomycin has antibacterial, antifungal, antineoplastic, immuno -suppressive activities. In addition, bafilomycin A1 has antimalarial activity. It has been shown to decrease multi-drug resistance. Bafilomycin B1 has been mentioned as a potential antioseoporotic agent in treating bone lytic diseases.