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Biomolecules

17-AAG, >99%, BC001

  • CAS Number : 75747-14-7
  • Formula : C31H43N3O8
  • MW : 585.69
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Cat No Size Price
BC001-025 25 mg $ 195.00 Add to cart
BC001-100 100 mg $ 460.00 Add to cart
IC50 5 nM
Target HSP90
Solubility DMSO : 100 mg/mL (170.73 mM)
Ethanol : 5 mg/mL (8.53 mM)
Water : Insoluble
Alternative Names NSC 330507,
17-(Allylamino)-17-demethoxygeldanamycin, Tanespimycin
17-AAG, an analog of geldanamycin, exhibits greater than 100 times higher binding affinity for Hsp90 derived from HER-2-overexpressing cancer cells (BT474, N87, SKOV3 and SKBR3) or BT474 breast carcinoma cells with IC50 values of 5-6 nM. 17-AAG causes the degradation of HER2, HER3, Akt, and both mutant and wild-type androgen receptor (AR), leading to the RB-dependent G1 growth arrest of prostate cancer cells such as LNCaP, LAPC-4, DU-145, and PC-3 with IC50 values of 25-45 nM. In addition to inducing apoptosis of Ba/F3 cells transformed with wild-type BCR-ABL with an IC50 of 5.2 μM, 17-AAG has the ability to induce apoptosis of cells transformed with imatinib mesylate-resistant T315I and E255K BCR-ABL mutants with IC50 values of 2.3 μM and 1.0 μM, respectively, by inducing the degradation of both wild-type BCR-ABL protein and mutants.